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KMID : 0931320170170020088
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대한상부위장관.헬리코박터학회지
2017 Volume.17 No. 2 p.88 ~ p.93
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Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma
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Yoon Jung-Bin
Kim Gwang-Ha
Park Do-Youn
Kim Young-Geum
Pyeon Sung-Ik
Lee Bong-Eun
Song Geun-Am
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Abstract
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Background/Aims: Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histologyresembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to earlylymph node or liver metastasis, but information concerning GHA is still limited. Therefore, we aimed to evaluate the clinicopathologicalfeatures of GHA.
Materials and Methods: We reviewed the medical records of 9 patients who were diagnosed as having GHA between January 2011and December 2016. The clinicopathological characteristics of these patients were retrospectively analyzed.
Results: The median age of the patients at diagnosis was 68.9 years. Seven of the 9 patients were male. Serum AFP levels were elevatedin 3 of 4 patients. All the tumors were ＞4 cm (range, 4∼12 cm), and 7 tumors were located at the lower third of the stomach.Five tumors were classified as Borrmann’s type 3, with a purple, berry-like surface. Of the 6 patients without distant metastasis, 5received curative-intent surgery and 3 received adjuvant chemotherapy. Three patients with distant metastasis received either palliativeoperation and/or chemotherapy. Their median survival time was 11.8 months (range, 1∼36 months). Two patients with elevatedserum CEA levels had poor outcomes.
Conclusions: GHA is a rare subtype of gastric cancer that is prone to liver metastasis. All GHAs are advanced gastric cancer witha purple, berry-like surface at diagnosis. Although the prognosis of advanced-stage GHA is poor, active multimodality treatmentmight provide some benefit.
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KEYWORD
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Adenocarcinoma, Chemotherapy, Endoscopy, Hepatocelluar carcinoma, Stomach
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